SLC1A5

Across TCGA pan-cancer cohorts, SLC1A5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLC1A5 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC1A5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC1A5 expression acts as an unfavorable survival marker, although some lineages such as STAD and COAD show a favorable association.

UVM, MESO, and LIHC are the cancer types where SLC1A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.403	0.742	<.001	103	view →
MESO	OS	Median	All	0.407	0.675	<.001	95	view →
LIHC	OS	Median	All	0.609	0.758	<.001	86	view →
KIRC	OS	Tertile	All	0.542	0.704	<.001	78	view →
BRCA	OS	Median	All	0.901	0.945	.002	67	view →
LGG	DFS	Median	All	0.285	0.528	<.001	49	view →
HNSC	OS	Tertile	All	0.303	0.586	<.001	36	view →
STAD	OS	Tertile	All	0.775	0.609	.005	31	view →
PAAD	DFS	Quartile	All	0.234	0.526	.002	28	view →
COAD	OS	Quartile	IV	0.904	0.413	.002	28	view →
ACC	DFS	Tertile	All	0.199	0.621	.003	22	view →
OV	OS	Tertile	All	0.273	0.352	.021	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLC1A5–UVM (DFS)

Open the UVM breakdown →