SLC1A4

Across TCGA pan-cancer cohorts, SLC1A4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC1A4 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SLC1A4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC1A4 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

CESC, STAD, and BLCA are the cancer types where SLC1A4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	30	view →
STAD	OS	Median	All	0.250	0.729	.028	6	view →
BLCA	DFS	Median	II,III,IV	1.000	0.333	.041	4	view →
UCEC	DFS	Median	II,III,IV	0.906	0.438	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC1A4–CESC (OS)

Open the CESC breakdown →