SLC1A2

Across TCGA patient cohorts, SLC1A2 mutation is significantly associated with the RNA expression of many other genes, with 4,688 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A2-associated genes across cancer lineages are C8orf89, TMEM138, and FAM177A1. Each is linked with SLC1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A2-to-partner and partner-to-SLC1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf89 grouped by SLC1A2-low versus SLC1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A2→partner) and Y-score (partner→SLC1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C8orf89 →	-0.231	-2.149	.006	.001	3	2
UCEC	TMEM138 →	+0.261	+2.425	<.001	<.001	3	2
UCEC	FAM177A1 →	+0.299	+2.254	.001	.005	3	2
UCEC	PI4K2A →	+0.358	+4.343	<.001	<.001	3	2
UCEC	ART3 →	-0.332	-1.485	.009	.003	3	2
SKCM	ANKRD9 →	+0.722	+3.341	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,688 associations by consensus.

C8orf89 by SLC1A2 expression — UCEC

Explore this box plot interactively →