SLC1A2

Across TCGA patient cohorts, SLC1A2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A2-associated genes across cancer lineages are PDCD4, VHL, and p62 Lck ligand. Each is linked with SLC1A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC1A2-to-partner and partner-to-SLC1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC1A2-low versus SLC1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A2→partner) and Y-score (partner→SLC1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.486	-1.906	.001	.014	3	3
UCEC	VHL →	-0.908	-1.925	<.001	.004	3	3
UCEC	p62 Lck ligand →	+0.417	+2.058	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.375	+1.720	.025	.025	3	2
SKCM	PDK1 →	+0.112	+3.000	.026	.034	3	2
SKCM	TIGAR →	+0.190	+3.334	.001	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PDCD4 by SLC1A2 expression — UCEC

Explore this box plot interactively →