SLC19A3

Across TCGA patient cohorts, SLC19A3 mutation is significantly associated with the RNA expression of many other genes, with 3,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC19A3-associated genes across cancer lineages are ACAT1, LIAS, and BBS7. Each is linked with SLC19A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC19A3-to-partner and partner-to-SLC19A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACAT1 grouped by SLC19A3-low versus SLC19A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC19A3→partner) and Y-score (partner→SLC19A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACAT1 →	+0.712	+2.115	<.001	<.001	3	3
UCEC	LIAS →	+0.370	+1.836	<.001	.001	3	3
UCEC	BBS7 →	+0.311	+2.127	.006	.002	3	3
UCEC	LINS1 →	+0.270	+2.353	.002	<.001	3	3
BRCA	RN7SL673P →	+0.159	+8.055	<.001	.007	3	2
COAD	IQCF1 →	+0.280	+3.879	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,246 associations by consensus.

ACAT1 by SLC19A3 expression — UCEC

Explore this box plot interactively →