SLC19A3

Across TCGA pan-cancer cohorts, SLC19A3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SLC19A3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SLC19A3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC19A3 expression acts as an unfavorable survival marker, although some lineages such as MESO and PAAD show a favorable association.

CESC, MESO, and UCEC are the cancer types where SLC19A3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.448	0.713	<.001	114	view →
MESO	OS	Median	All	0.672	0.412	<.001	96	view →
UCEC	DFS	Tertile	All	0.780	0.905	<.001	92	view →
LGG	OS	Median	All	0.328	0.555	<.001	49	view →
BLCA	OS	Quartile	II,III,IV	0.523	0.695	.003	46	view →
PAAD	OS	Tertile	II,III,IV	0.699	0.473	.001	42	view →
UVM	OS	Median	All	1.000	0.493	.010	32	view →
SKCM	OS	Median	II,III,IV	0.677	0.787	.004	28	view →
LUSC	DFS	Tertile	II,III,IV	0.647	0.789	.006	25	view →
ACC	DFS	Quartile	All	0.467	0.833	.002	24	view →
KIRP	OS	Median	II,III,IV	0.752	0.355	.009	24	view →
BRCA	OS	Median	III,IV	0.648	0.426	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SLC19A3–CESC (OS)

Open the CESC breakdown →