SLC19A3

Across TCGA patient cohorts, SLC19A3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC19A3-associated genes across cancer lineages are eIF4E, MSH2, and Myosin-IIa. Each is linked with SLC19A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC19A3-to-partner and partner-to-SLC19A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC19A3-low versus SLC19A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC19A3→partner) and Y-score (partner→SLC19A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.162	+1.807	.024	.004	3	2
UCEC	MSH2 →	-0.270	-2.674	<.001	.005	3	2
UCEC	Myosin-IIa →	+0.180	+1.933	.007	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.593	+2.434	.003	.001	3	2
UCEC	14-3-3_beta →	-0.094	-2.195	.006	.009	3	1
UCEC	ERK2 →	+0.197	+1.514	.002	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by SLC19A3 expression — UCEC

Explore this box plot interactively →