SLC19A1

Across TCGA patient cohorts, SLC19A1 mutation is significantly associated with the RNA expression of many other genes, with 1,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC19A1-associated genes across cancer lineages are FRG2GP, RN7SL447P, and HNRNPMP2. Each is linked with SLC19A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC19A1-to-partner and partner-to-SLC19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG2GP grouped by SLC19A1-low versus SLC19A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC19A1→partner) and Y-score (partner→SLC19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FRG2GP →	+0.104	+3.770	<.001	.005	3	3
UCEC	RN7SL447P →	+0.121	+1.904	.001	.005	3	3
CESC	HNRNPMP2 →	+0.047	+4.757	<.001	.004	3	2
COAD	TRAJ45 →	+0.811	+4.407	.004	.001	3	2
COAD	PINCR →	+0.327	+4.120	.001	.002	3	2
CESC	RNA5SP198 →	+0.224	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

FRG2GP by SLC19A1 expression — HNSC

Explore this box plot interactively →