Across TCGA cell cohorts, SLC18A3 mutation is significantly associated with the RNA expression of many other genes, with 1,065 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC18A3-associated genes across cancer lineages are KHDC3L, ZBED4, and CUEDC2. Each is linked with SLC18A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC18A3-to-partner and partner-to-SLC18A3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC18A3→partner) and Y-score (partner→SLC18A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KHDC3L →	+0.023	+5.217	<.001	<.001	3	2
LARGE_INTESTINE	ZBED4 →	+0.461	+2.596	.004	.002	3	2
LARGE_INTESTINE	CUEDC2 →	+0.519	+2.523	.001	.003	3	2
LARGE_INTESTINE	CRACD →	+0.921	+2.364	.001	<.001	3	2
LARGE_INTESTINE	VPS4B →	+0.625	+2.364	.001	<.001	3	2
LARGE_INTESTINE	RNF138 →	+0.705	+1.850	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,065 associations by consensus.

Exploration

SLC18A3 survival (RNA) · tumor vs normal (RNA) · all SLC18A3 data types