SLC15A3

Across TCGA patient cohorts, SLC15A3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC15A3-associated genes across cancer lineages are Notch1, STAT5a, and EGFR_pY1068. Each is linked with SLC15A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC15A3-to-partner and partner-to-SLC15A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SLC15A3-low versus SLC15A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A3→partner) and Y-score (partner→SLC15A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.211	+3.183	.001	.009	3	2
UCEC	STAT5a →	+0.437	+3.169	.019	.019	3	2
UCEC	EGFR_pY1068 →	-0.239	-3.000	.041	.036	3	1
UCEC	ERK2 →	+0.226	+2.321	.011	.034	3	1
UCEC	FoxM1 →	+0.263	+2.584	.029	.011	3	1
UCEC	MEK1 →	+0.444	+3.459	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by SLC15A3 expression — UCEC

Explore this box plot interactively →