SLC15A3

Across TCGA pan-cancer cohorts, SLC15A3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC15A3 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SLC15A3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC15A3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, CESC, and LGG are the cancer types where SLC15A3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.402	0.249	<.001	104	view →
CESC	OS	Tertile	All	0.646	0.419	<.001	80	view →
LGG	DFS	Median	All	0.663	0.810	<.001	48	view →
LAML	DFS	Tertile	All	0.380	0.794	.001	36	view →
ACC	OS	Tertile	II,III,IV	0.694	0.963	.005	31	view →
CHOL	DFS	Quartile	II,III,IV	0.798	0.185	.007	28	view →
HNSC	DFS	Tertile	All	0.693	0.537	.004	20	view →
SARC	OS	Median	All	0.811	0.674	.002	18	view →
LIHC	DFS	Median	III,IV	0.368	0.174	.012	16	view →
PAAD	DFS	Median	II,III,IV	0.363	0.197	.009	15	view →
UVM	DFS	Tertile	All	0.414	0.739	.008	14	view →
KIRC	DFS	Median	IV	0.240	0.423	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC15A3–SKCM (OS)

Open the SKCM breakdown →