SLC15A3

Across TCGA cell cohorts, SLC15A3 mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC15A3-associated genes across cancer lineages are PTH, TCP10L2, and FAM71B. Each is linked with SLC15A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC15A3-to-partner and partner-to-SLC15A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by SLC15A3-low versus SLC15A3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A3→partner) and Y-score (partner→SLC15A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTH →	+0.034	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.064	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM71B →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KIR3DL3 →	+0.039	+5.228	<.001	.005	3	1
LARGE_INTESTINE	GCAT →	+1.305	+3.364	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

PTH by SLC15A3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →