SLC15A2

Across TCGA cell cohorts, SLC15A2 mutation is significantly associated with the mutation status of many other genes, with 2,384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC15A2-associated genes across cancer lineages are FRAS1, OR2L13, and CLCA1. Each is linked with SLC15A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC15A2-to-partner and partner-to-SLC15A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRAS1 grouped by SLC15A2-low versus SLC15A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A2→partner) and Y-score (partner→SLC15A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FRAS1 →	+1.914	+3.185	.001	.001	1	4
BLOOD_Leukemia	OR2L13 →	+3.430	+3.313	.005	.005	1	4
SKIN	CLCA1 →	+4.239	+5.053	.007	.007	1	4
SKIN	GSN →	+4.824	+5.392	.004	.004	1	4
BREAST	SCIN →	+3.389	+3.389	.001	.001	1	3
PANCREAS	SNPH →	+5.115	+5.115	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,384 associations by consensus.

FRAS1 by SLC15A2 expression — LARGE_INTESTINE

Explore this box plot interactively →