SLC15A1

Across TCGA cell cohorts, SLC15A1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLC15A1-associated genes across cancer lineages are MT4, GJA10, and GUCA2A. Each is linked with SLC15A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC15A1-to-partner and partner-to-SLC15A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by SLC15A1-low versus SLC15A1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC15A1→partner) and Y-score (partner→SLC15A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MT4 →	+0.155	+5.169	<.001	.005	3	1
BREAST	GJA10 →	+0.039	+5.169	<.001	.005	3	1
CNS	GUCA2A →	+0.068	+5.321	<.001	.005	3	1
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	1
BLOOD_Leukemia	OR8D4 →	+0.006	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MT4 by SLC15A1 expression — BREAST

Explore this box plot interactively →