SLC13A2

Across TCGA patient cohorts, SLC13A2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC13A2-associated genes across cancer lineages are FASN, MEK1, and Tuberin. Each is linked with SLC13A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC13A2-to-partner and partner-to-SLC13A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SLC13A2-low versus SLC13A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC13A2→partner) and Y-score (partner→SLC13A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.286	+1.906	.025	.015	3	2
UCEC	MEK1 →	+0.349	+1.925	.003	.004	3	2
UCEC	Tuberin →	+0.336	+2.000	<.001	<.001	3	2
SKCM	MAPK_pT202_Y204 →	+0.456	+1.584	.008	.035	3	1
SKCM	S6_pS235_S236 →	+0.431	+1.749	.009	.049	3	1
UCEC	14-3-3_beta →	-0.092	-2.295	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FASN by SLC13A2 expression — UCEC

Explore this box plot interactively →