SLC13A2

Across TCGA pan-cancer cohorts, SLC13A2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SLC13A2 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC13A2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC13A2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ACC show a favorable association.

HNSC, ACC, and LUSC are the cancer types where SLC13A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.702	0.553	<.001	138	view →
ACC	OS	Tertile	All	0.919	0.627	.001	77	view →
LUSC	DFS	Median	II,III,IV	0.523	0.283	<.001	77	view →
SCLC	OS	Tertile	II,III,IV	0.177	0.908	<.001	42	view →
CESC	OS	Median	III,IV	0.789	0.454	.005	40	view →
ESCA	OS	Median	All	0.427	1.000	.007	31	view →
LUAD	DFS	Median	IV	0.256	0.729	.006	24	view →
SKCM	OS	Tertile	IV	0.307	0.700	.027	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
KIRC	DFS	Quartile	All	0.757	0.528	.001	13	view →
KIRP	DFS	Median	II,III,IV	0.813	0.544	.021	9	view →
STAD	OS	Tertile	IV	0.755	0.288	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SLC13A2–HNSC (DFS)

Open the HNSC breakdown →