SLC13A1

Across TCGA patient cohorts, SLC13A1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC13A1-associated genes across cancer lineages are p62 Lck ligand, Rab25, and Rad50. Each is linked with SLC13A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC13A1-to-partner and partner-to-SLC13A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SLC13A1-low versus SLC13A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC13A1→partner) and Y-score (partner→SLC13A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.405	+1.954	<.001	<.001	3	2
UCEC	Rab25 →	-0.318	-3.906	<.001	<.001	3	2
UCEC	Rad50 →	-0.186	-1.347	.007	.006	3	2
UCEC	Shc_pY317 →	-0.108	-1.584	.013	.015	3	2
UCEC	Caspase-8 →	-0.254	-1.736	<.001	<.001	3	2
LUSC	PEA-15 →	+0.345	+3.009	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p62 Lck ligand by SLC13A1 expression — UCEC

Explore this box plot interactively →