SLC12A9

Across TCGA cell cohorts, SLC12A9 mutation is significantly associated with the RNA expression of many other genes, with 347 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A9-associated genes across cancer lineages are HES3, DEFB133, and RBMY1A1. Each is linked with SLC12A9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A9-to-partner and partner-to-SLC12A9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HES3 grouped by SLC12A9-low versus SLC12A9-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A9→partner) and Y-score (partner→SLC12A9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	1
CNS	DEFB133 →	+0.035	+5.357	<.001	.001	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	ZBTB16 →	+0.395	+3.482	<.001	.008	3	1
LUNG_NSCLC_LUAD	PRMT8 →	+0.422	+3.602	<.001	.006	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.482	+3.157	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 347 associations by consensus.

HES3 by SLC12A9 expression — CNS

Explore this box plot interactively →