SLC12A9

Across TCGA pan-cancer cohorts, SLC12A9 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLC12A9 data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC12A9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC12A9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

UVM, HNSC, and OV are the cancer types where SLC12A9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.431	0.740	<.001	114	view →
HNSC	OS	Tertile	II,III,IV	0.510	0.287	<.001	72	view →
OV	OS	Quartile	III,IV	0.291	0.457	.001	54	view →
KIRC	DFS	Quartile	All	0.710	0.862	.003	47	view →
LGG	DFS	Median	All	0.634	0.836	<.001	44	view →
COAD	OS	Median	All	0.538	0.671	.009	24	view →
UCEC	DFS	Median	All	0.794	0.879	.003	22	view →
STAD	OS	Median	All	0.469	0.292	.010	21	view →
ACC	DFS	Tertile	II,III,IV	0.240	0.610	.004	21	view →
KICH	OS	Quartile	II,III,IV	0.390	1.000	.001	19	view →
LUAD	OS	Tertile	All	0.378	0.249	.005	18	view →
LIHC	OS	Quartile	All	0.692	0.836	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLC12A9–UVM (DFS)

Open the UVM breakdown →