SLC12A4

Across TCGA patient cohorts, SLC12A4 mutation is significantly associated with the RNA expression of many other genes, with 4,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A4-associated genes across cancer lineages are VAPA, RNA5SP499, and RNU7-43P. Each is linked with SLC12A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC12A4-to-partner and partner-to-SLC12A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAPA grouped by SLC12A4-low versus SLC12A4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A4→partner) and Y-score (partner→SLC12A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VAPA →	+0.425	+2.335	.002	.003	3	4
THCA	RNA5SP499 →	+0.238	+7.962	<.001	.007	3	3
SKCM	RNU7-43P →	+0.673	+3.164	<.001	.003	3	3
COAD	MTA2 →	+0.325	+3.391	.002	.004	3	3
UCEC	MPPE1 →	+0.412	+1.969	<.001	.002	3	3
UCEC	EME1 →	+0.537	+2.055	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,228 associations by consensus.

VAPA by SLC12A4 expression — COAD

Explore this box plot interactively →