SLC12A4

Across TCGA pan-cancer cohorts, SLC12A4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SLC12A4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC12A4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC12A4 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where SLC12A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC12A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.296	<.001	11	view →
KIRC	Female	All	+0.821	<.001	11	view →
LUAD	Female	All	−0.968	<.001	9	view →
LIHC	Female	II,III,IV	+1.229	<.001	8	view →
COAD	Female	All	+0.810	<.001	8	view →
KIRP	Female	All	+0.695	.008	8	view →
THCA	All	II,III,IV	−0.586	<.001	8	view →
KICH	Male	All	−1.081	<.001	7	view →
UCEC	All	All	−1.536	<.001	6	view →
LUSC	Female	All	−1.321	<.001	6	view →
BRCA	All	All	−0.933	<.001	6	view →
BLCA	Male	III,IV	−0.918	.005	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SLC12A4–HNSC

Open the HNSC breakdown →