SLC12A4

Across TCGA cell cohorts, SLC12A4 mutation is significantly associated with the RNA expression of many other genes, with 782 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A4-associated genes across cancer lineages are MAPK8, C12orf57, and TTC33. Each is linked with SLC12A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A4-to-partner and partner-to-SLC12A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK8 grouped by SLC12A4-low versus SLC12A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A4→partner) and Y-score (partner→SLC12A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAPK8 →	+0.767	+3.169	<.001	.006	3	2
LARGE_INTESTINE	C12orf57 →	+0.808	+2.628	.001	.002	3	2
LARGE_INTESTINE	TTC33 →	+0.659	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CEP70 →	+0.705	+2.628	.006	.002	3	2
LARGE_INTESTINE	PAPOLG →	+0.378	+2.714	.003	.002	3	2
LARGE_INTESTINE	OSCP1 →	+0.679	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 782 associations by consensus.

MAPK8 by SLC12A4 expression — LARGE_INTESTINE

Explore this box plot interactively →