SLC12A2

Across TCGA patient cohorts, SLC12A2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC12A2-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and Heregulin. Each is linked with SLC12A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A2-to-partner and partner-to-SLC12A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC12A2-low versus SLC12A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A2→partner) and Y-score (partner→SLC12A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.241	-1.536	<.001	.002	3	2
UCEC	GAPDH →	+0.396	+1.169	.010	.017	3	2
UCEC	Heregulin →	-0.075	-1.169	.035	.017	3	2
UCEC	MEK1 →	+0.431	+1.736	<.001	<.001	3	2
UCEC	N-Ras →	-0.078	-1.342	.023	.034	3	2
UCEC	p62 Lck ligand →	+0.242	+1.169	.009	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR_pY1068 by SLC12A2 expression — UCEC

Explore this box plot interactively →