SLC12A2

Across TCGA pan-cancer cohorts, SLC12A2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC12A2 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SLC12A2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC12A2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

BLCA, KIRC, and HNSC are the cancer types where SLC12A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.426	0.705	.001	94	view →
KIRC	OS	Median	All	0.727	0.551	<.001	86	view →
HNSC	DFS	Quartile	All	0.737	0.521	<.001	61	view →
READ	DFS	Tertile	All	0.810	0.278	.001	57	view →
ACC	DFS	Tertile	All	0.367	0.773	<.001	50	view →
LIHC	OS	Quartile	II,III,IV	0.333	0.694	.003	31	view →
UCEC	OS	Median	All	0.908	0.838	.006	28	view →
LUSC	DFS	Median	All	0.646	0.332	<.001	28	view →
COAD	OS	Median	II,III,IV	0.877	0.692	.004	27	view →
SARC	DFS	Tertile	All	0.255	0.512	.005	25	view →
UCS	DFS	Tertile	II,III,IV	0.228	0.531	.009	24	view →
UVM	DFS	Quartile	All	0.364	0.842	.009	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SLC12A2–BLCA (OS)

Open the BLCA breakdown →