SLC12A2

Across TCGA cell cohorts, SLC12A2 mutation is significantly associated with the RNA expression of many other genes, with 235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC12A2-associated genes across cancer lineages are AVP, DENND3, and MAP3K8. Each is linked with SLC12A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC12A2-to-partner and partner-to-SLC12A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by SLC12A2-low versus SLC12A2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC12A2→partner) and Y-score (partner→SLC12A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AVP →	+0.072	+4.981	<.001	<.001	3	2
LARGE_INTESTINE	DENND3 →	-0.890	-3.243	.004	.003	3	2
LARGE_INTESTINE	MAP3K8 →	-0.886	-3.416	.001	.002	3	2
LARGE_INTESTINE	TTC33 →	+0.612	+3.502	.004	.001	3	2
LARGE_INTESTINE	GSN →	-1.731	-3.416	<.001	.002	3	2
LARGE_INTESTINE	REG1B →	+1.432	+2.196	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 235 associations by consensus.

AVP by SLC12A2 expression — CNS

Explore this box plot interactively →