SLC10A3

Across TCGA patient cohorts, SLC10A3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC10A3-associated genes across cancer lineages are ERK2, NF2, and S6_pS240_S244. Each is linked with SLC10A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC10A3-to-partner and partner-to-SLC10A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLC10A3-low versus SLC10A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC10A3→partner) and Y-score (partner→SLC10A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.171	+2.321	.013	.001	3	2
UCEC	NF2 →	+0.207	+2.459	.008	.018	3	2
UCEC	S6_pS240_S244 →	+0.336	+2.000	.021	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.777	+2.926	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.276	+2.614	.004	.005	3	2
UCEC	C-Raf →	+0.149	+2.115	.003	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ERK2 by SLC10A3 expression — UCEC

Explore this box plot interactively →