SLC10A3

Across TCGA pan-cancer cohorts, SLC10A3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SLC10A3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC10A3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC10A3 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where SLC10A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC10A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.214	<.001	12	view →
COAD	Female	All	+0.669	<.001	10	view →
LIHC	Female	II,III,IV	+1.186	<.001	9	view →
KICH	Male	All	−1.016	<.001	9	view →
THCA	Male	III,IV	−0.637	<.001	7	view →
KIRP	All	II,III,IV	+0.650	.004	6	view →
LUSC	Male	All	+0.559	<.001	6	view →
KIRC	Female	All	+0.523	<.001	6	view →
STAD	All	II,III,IV	+0.751	<.001	4	view →
CHOL	Male	All	+2.836	<.001	3	view →
LUAD	Female	II,III,IV	+0.389	.019	2	view →
READ	All	All	+0.377	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SLC10A3–HNSC

Open the HNSC breakdown →