SLC10A2

Across TCGA cell cohorts, SLC10A2 mutation is significantly associated with the mutation status of many other genes, with 1,400 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC10A2-associated genes across cancer lineages are DCC, KAZN, and HIVEP3. Each is linked with SLC10A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC10A2-to-partner and partner-to-SLC10A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCC grouped by SLC10A2-low versus SLC10A2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC10A2→partner) and Y-score (partner→SLC10A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DCC →	+3.263	+3.851	.005	.005	1	4
BLOOD_Leukemia	KAZN →	+4.321	+5.285	.005	.005	1	4
BLOOD_Lymphoma	HIVEP3 →	+2.847	+4.327	.006	.006	1	4
LARGE_INTESTINE	SASH1 →	+2.974	+4.643	<.001	<.001	1	4
SKIN	AKAP12 →	+3.321	+3.035	.008	.008	1	3
LUNG_SCLC	UBR3 →	+5.066	+4.502	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,400 associations by consensus.

DCC by SLC10A2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →