SLAMF8

Across TCGA patient cohorts, SLAMF8 mutation is significantly associated with the RNA expression of many other genes, with 1,077 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF8-associated genes across cancer lineages are RNU6-770P, FBXO7, and PACSIN2. Each is linked with SLAMF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLAMF8-to-partner and partner-to-SLAMF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-770P grouped by SLAMF8-low versus SLAMF8-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF8→partner) and Y-score (partner→SLAMF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-770P →	+0.540	+4.429	<.001	.006	3	3
UCEC	FBXO7 →	+0.410	+2.625	.004	.005	3	2
UCEC	PACSIN2 →	+0.513	+3.459	.001	.005	3	2
UCEC	ACD →	+0.568	+3.343	<.001	.005	3	2
UCEC	VAC14 →	+0.471	+3.584	<.001	.002	3	2
UCEC	MON1B →	+0.500	+3.491	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,077 associations by consensus.

RNU6-770P by SLAMF8 expression — BLCA

Explore this box plot interactively →