SLAMF8

Across TCGA pan-cancer cohorts, SLAMF8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLAMF8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLAMF8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLAMF8 is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where SLAMF8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLAMF8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.876	<.001	12	view →
HNSC	All	III,IV	+1.465	<.001	12	view →
KIRP	Male	All	+1.543	<.001	9	view →
STAD	All	II,III,IV	+1.990	<.001	8	view →
LIHC	Female	II,III,IV	+1.212	<.001	8	view →
BLCA	All	All	+0.911	.013	7	view →
BRCA	All	II,III,IV	+1.308	<.001	6	view →
THCA	Male	II,III,IV	+1.204	.006	5	view →
ESCA	All	All	+1.640	.016	2	view →
UCEC	All	III,IV	+0.921	.038	2	view →
PRAD	All	All	+0.330	.037	2	view →
CHOL	All	All	+1.904	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLAMF8–KIRC

Open the KIRC breakdown →