SLAMF8

Across TCGA patient cohorts, SLAMF8 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF8-associated genes across cancer lineages are IGFBP2, JNK2, and mTOR_pS2448. Each is linked with SLAMF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF8-to-partner and partner-to-SLAMF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by SLAMF8-low versus SLAMF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF8→partner) and Y-score (partner→SLAMF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.836	-2.807	.003	.003	3	1
UCEC	JNK2 →	+0.247	+1.884	.004	.030	3	1
UCEC	mTOR_pS2448 →	-0.146	-1.861	.024	.049	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.391	-2.321	.046	.034	3	1
UCEC	VHL →	-0.878	-2.807	.003	.003	3	1
UCEC	Caspase-8 →	-0.253	-3.558	.021	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IGFBP2 by SLAMF8 expression — UCEC

Explore this box plot interactively →