SLAMF8

Across TCGA cell cohorts, SLAMF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,855 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLAMF8-associated GO terms across cancer lineages are T-helper 17 cell lineage commitment, Regulation of integrin-mediated signaling pathway, and Protein localization to lysosome. Each is linked with SLAMF8 in more than 6 cancer types. Because this analysis shows association rather than direction, both SLAMF8-to-partner and partner-to-SLAMF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T-helper 17 cell lineage commitment grouped by SLAMF8-low versus SLAMF8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF8→partner) and Y-score (partner→SLAMF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	T-helper 17 cell lineage commitment →	+0.246	+0.751	<.001	.007	3	7
BLOOD_Leukemia	Regulation of integrin-mediated signaling pathway →	+0.094	+0.563	.005	.004	3	7
SKIN	Protein localization to lysosome →	+0.043	+0.121	.008	.008	3	6
CNS	Bile acid signaling pathway →	-0.204	-0.253	<.001	<.001	3	6
BLOOD_Leukemia	Multivesicular body organization →	+0.053	+0.493	<.001	.003	3	6
SKIN	Dendritic cell migration →	-0.094	-0.117	.003	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,855 associations by consensus.

T-helper 17 cell lineage commitment by SLAMF8 expression — SOFT_TISSUE

Explore this box plot interactively →