SLAMF1

Across TCGA cell cohorts, SLAMF1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLAMF1-associated genes across cancer lineages are OR1L3, CLPSL1, and MINAR2. Each is linked with SLAMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF1-to-partner and partner-to-SLAMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by SLAMF1-low versus SLAMF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF1→partner) and Y-score (partner→SLAMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	2
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1
SKIN	MINAR2 →	+0.013	+4.977	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR1L3 by SLAMF1 expression — SKIN

Explore this box plot interactively →