SLAIN1

Across TCGA patient cohorts, SLAIN1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SLAIN1-associated genes across cancer lineages are FASN, p27_pT157, and p62 Lck ligand. Each is linked with SLAIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAIN1-to-partner and partner-to-SLAIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SLAIN1-low versus SLAIN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAIN1→partner) and Y-score (partner→SLAIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.444	+2.178	.015	.035	3	2
UCEC	p27_pT157 →	-0.048	-1.847	.024	.008	3	2
UCEC	p62 Lck ligand →	+0.255	+2.232	.032	.005	3	2
COAD	PCNA →	+0.277	+2.178	.017	.035	3	2
COAD	PDCD4 →	-0.511	-3.313	.009	.010	3	2
UCEC	Rad50 →	-0.200	-1.502	.024	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FASN by SLAIN1 expression — COAD

Explore this box plot interactively →