SLAIN1

Across TCGA pan-cancer cohorts, SLAIN1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SLAIN1 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SLAIN1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLAIN1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

BRCA, UCEC, and HNSC are the cancer types where SLAIN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.592	0.450	<.001	80	view →
UCEC	DFS	Tertile	III,IV	0.911	0.670	<.001	76	view →
HNSC	DFS	Tertile	IV	0.732	0.538	<.001	62	view →
MESO	OS	Tertile	All	0.628	0.335	<.001	56	view →
LGG	DFS	Median	All	0.489	0.326	<.001	30	view →
OV	OS	Tertile	II,III,IV	0.916	0.799	.003	26	view →
THYM	OS	Median	All	1.000	0.731	.001	24	view →
ACC	OS	Tertile	III,IV	0.755	0.196	.009	21	view →
LUAD	OS	Quartile	All	0.865	0.697	.005	20	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	18	view →
STAD	OS	Median	II,III,IV	0.595	0.721	.022	15	view →
PAAD	DFS	Median	All	0.424	0.291	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SLAIN1–BRCA (DFS)

Open the BRCA breakdown →