SLAIN1

Across TCGA cell cohorts, SLAIN1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SLAIN1-associated genes across cancer lineages are H1-8, KRTAP4-2, and CYP11B1. Each is linked with SLAIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAIN1-to-partner and partner-to-SLAIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-8 grouped by SLAIN1-low versus SLAIN1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAIN1→partner) and Y-score (partner→SLAIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	H1-8 →	+0.059	+5.196	<.001	.005	3	1
OVARY	KRTAP4-2 →	+0.035	+5.196	<.001	.005	3	1
LUNG_SCLC	CYP11B1 →	+0.019	+4.169	<.001	.001	3	1
LUNG_SCLC	CD300LG →	+0.060	+3.750	<.001	.007	3	1
LUNG_SCLC	FCRL4 →	+0.010	+4.058	<.001	.007	3	1
LUNG_SCLC	FOXR1 →	+0.227	+3.736	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

H1-8 by SLAIN1 expression — OVARY

Explore this box plot interactively →