SKIL

Across TCGA pan-cancer cohorts, SKIL Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SKIL data layer compared with 23 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SKIL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SKIL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, BLCA, and UCEC are the cancer types where SKIL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.129	0.785	.002	12	view →
BLCA	DFS	Median	III,IV	0.188	0.574	.036	6	view →
UCEC	DFS	Median	II,III,IV	0.915	0.307	.029	6	view →
SKCM	DFS	Median	IV	0.016	0.454	<.001	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SKIL–COAD (OS)

Open the COAD breakdown →