SKIL

Across TCGA pan-cancer cohorts, SKIL RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SKIL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SKIL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SKIL is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where SKIL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SKIL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.609	<.001	12	view →
BLCA	Male	III,IV	+1.822	.001	8	view →
STAD	All	II,III,IV	+0.911	<.001	8	view →
BRCA	All	II,III,IV	+0.909	<.001	6	view →
CHOL	Male	All	+1.898	<.001	5	view →
KICH	All	All	−0.986	<.001	5	view →
ESCA	All	All	+1.451	.002	3	view →
UCEC	All	II,III,IV	+0.935	.013	2	view →
READ	All	All	+0.847	.002	2	view →
COAD	Male	All	+0.832	<.001	2	view →
THCA	All	III,IV	+0.501	.019	2	view →
LUSC	All	All	+0.494	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SKIL–HNSC

Open the HNSC breakdown →