SKIL

Across TCGA patient cohorts, SKIL protein abundance is significantly associated with the RNA expression of many other genes, with 6,024 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SKIL-associated genes across cancer lineages are NRL, INPP5B, and OSBPL10-AS1. Each is linked with SKIL in more than 1 cancer types. Because this analysis shows association rather than direction, both SKIL-to-partner and partner-to-SKIL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SKIL versus NRL in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKIL→partner) and Y-score (partner→SKIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NRL →	+0.284	+0.458	.005	.006	3	2
LUAD	INPP5B →	-1.134	-0.667	<.001	.007	3	2
LUAD	OSBPL10-AS1 →	-1.210	-0.552	<.001	.002	3	2
BRCA	NANOGNBP3 →	-0.498	-0.557	.008	.003	3	2
LSCC	FAM83D →	+1.292	+0.514	.001	.002	3	1
LUAD	RASL12 →	-1.150	-0.632	.005	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,024 associations by consensus.

SKIL vs NRL — BRCA

Explore this scatter interactively →