SKIL

Across TCGA cell cohorts, SKIL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,048 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SKIL-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Stress granule assembly, and Protein targeting to vacuole. Each is linked with SKIL in more than 13 cancer types. Because this analysis shows association rather than direction, both SKIL-to-partner and partner-to-SKIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by SKIL-low versus SKIL-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SKIL→partner) and Y-score (partner→SKIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of cytoplasmic translation →	+0.139	+1.543	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Stress granule assembly →	+0.114	+0.884	<.001	.001	3	14
OVARY	Protein targeting to vacuole →	+0.080	+1.663	<.001	<.001	3	13
BLOOD_Lymphoma	Protein exit from endoplasmic reticulum →	+0.135	+1.503	<.001	<.001	3	13
BLOOD_Lymphoma	Protein modification by small protein removal →	+0.048	+1.419	<.001	<.001	3	13
STOMACH	Endosomal transport →	+0.050	+1.577	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,048 associations by consensus.

Positive regulation of cytoplasmic translation by SKIL expression — OVARY

Explore this box plot interactively →