SKIL

Across TCGA cell cohorts, SKIL mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SKIL-associated genes across cancer lineages are SIGLEC5, PTF1A, and OR6X1. Each is linked with SKIL in more than 1 cancer types. Because this analysis shows association rather than direction, both SKIL-to-partner and partner-to-SKIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by SKIL-low versus SKIL-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKIL→partner) and Y-score (partner→SKIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIGLEC5 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	PTF1A →	+0.346	+4.906	<.001	.006	3	1
OESOPHAGUS	OR6X1 →	+0.020	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	BANF2 →	+0.035	+4.643	.003	.005	3	1
BLOOD_Lymphoma	C20orf173 →	+0.070	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	GJD2 →	+0.012	+5.794	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

SIGLEC5 by SKIL expression — OESOPHAGUS

Explore this box plot interactively →