SKAP1

Across TCGA pan-cancer cohorts, SKAP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SKAP1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SKAP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SKAP1 expression acts as an unfavorable survival marker.

ESCA, CESC, and UCEC are the cancer types where SKAP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.121	0.705	<.001	36	view →
CESC	OS	Median	All	0.615	0.874	.018	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	All	0.623	0.872	.038	3	view →
SKCM	DFS	Median	III,IV	0.172	0.653	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SKAP1–ESCA (OS)

Open the ESCA breakdown →