SKAP1

Across TCGA pan-cancer cohorts, SKAP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SKAP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SKAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SKAP1 is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where SKAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SKAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+1.064	<.001	10	view →
KIRC	All	II,III,IV	−0.875	<.001	10	view →
LIHC	Male	All	−1.291	<.001	8	view →
BRCA	All	III,IV	+1.799	<.001	6	view →
LUSC	Male	III,IV	−2.434	<.001	5	view →
KICH	All	All	−1.267	<.001	5	view →
STAD	All	All	+1.055	<.001	5	view →
ESCA	All	II,III,IV	+2.290	.007	3	view →
CHOL	All	II,III,IV	−2.479	.025	2	view →
READ	Female	All	+2.421	.003	2	view →
PRAD	All	All	−0.539	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SKAP1–COAD

Open the COAD breakdown →