SKAP1

Across TCGA pan-cancer cohorts, SKAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SKAP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SKAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SKAP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SKAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	1.000	0.157	.006	33	view →
LUAD	DFS	Tertile	All	0.883	0.524	<.001	18	view →
HNSC	DFS	Median	III,IV	0.426	0.767	.002	18	view →
UCEC	DFS	Quartile	All	0.822	1.000	.017	14	view →
PDAC	DFS	Median	II,III,IV	0.409	0.597	.034	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SKAP1–CCRCC (DFS)

Open the CCRCC breakdown →