SKAP1

Across TCGA patient cohorts, SKAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,343 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKAP1-associated genes across cancer lineages are CCL4, TXN2, and DHODH. Each is linked with SKAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKAP1-to-partner and partner-to-SKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by SKAP1-low versus SKAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKAP1→partner) and Y-score (partner→SKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+0.821	+2.928	.005	.001	3	2
UCEC	TXN2 →	+0.369	+3.724	.003	<.001	3	2
UCEC	DHODH →	+0.413	+2.917	.001	.001	3	2
UCEC	IL21R →	+0.583	+3.624	.001	.001	3	2
UCEC	ZNF106 →	+0.641	+2.906	<.001	.002	3	2
UCEC	KCTD9 →	+0.769	+3.491	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,343 associations by consensus.

CCL4 by SKAP1 expression — UCEC

Explore this box plot interactively →