SKAP1

Across TCGA patient cohorts, SKAP1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKAP1-associated genes across cancer lineages are mTOR_pS2448, c-Met_pY1235, and 14-3-3_beta. Each is linked with SKAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKAP1-to-partner and partner-to-SKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SKAP1-low versus SKAP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKAP1→partner) and Y-score (partner→SKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.200	-3.169	.021	.018	3	2
SKCM	c-Met_pY1235 →	+0.121	+2.459	.002	.020	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.045	.035	3	2
UCEC	eEF2 →	+0.412	+3.000	.013	.036	3	2
UCEC	JNK2 →	+0.254	+2.584	.006	.011	3	2
UCEC	TFRC →	+0.642	+3.000	.009	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

mTOR_pS2448 by SKAP1 expression — SKCM

Explore this box plot interactively →