SKA1

Across TCGA patient cohorts, SKA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKA1-associated genes across cancer lineages are Notch1, Annexin-1, and Tuberin. Each is linked with SKA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKA1-to-partner and partner-to-SKA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SKA1-low versus SKA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA1→partner) and Y-score (partner→SKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+3.169	.030	.020	3	1
UCEC	Annexin-1 →	+0.794	+2.827	.005	.035	3	1
UCEC	Tuberin →	+0.488	+3.009	<.001	.019	3	1
UCEC	C-Raf →	+0.193	+3.169	.014	.020	3	1
UCEC	Caspase-8 →	-0.320	-3.000	.020	.036	2	1
UCEC	4E-BP1 →	+0.341	+3.169	.021	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by SKA1 expression — UCEC

Explore this box plot interactively →