SKA1

Across TCGA cell cohorts, SKA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,828 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SKA1-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of chromosome separation, and Regulation of mitotic metaphase/anaphase transition. Each is linked with SKA1 in more than 19 cancer types. Because this analysis shows association rather than direction, both SKA1-to-partner and partner-to-SKA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by SKA1-low versus SKA1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA1→partner) and Y-score (partner→SKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.132	+1.299	<.001	<.001	3	20
SOFT_TISSUE	Regulation of chromosome separation →	+0.183	+0.922	<.001	<.001	3	20
SOFT_TISSUE	Regulation of mitotic metaphase/anaphase transition →	+0.139	+0.958	<.001	<.001	3	20
SOFT_TISSUE	Regulation of mitotic sister chromatid segregation →	+0.173	+1.051	<.001	<.001	3	20
SOFT_TISSUE	Establishment of meiotic spindle orientation →	+0.211	+1.321	<.001	<.001	3	20
BLOOD_Myeloma	Spindle assembly involved in female meiosis →	+0.221	+1.756	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,828 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by SKA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →