Across TCGA patient cohorts, SIX6 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX6-associated genes across cancer lineages are ERK2, GAPDH, and NDRG1_pT346. Each is linked with SIX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX6-to-partner and partner-to-SIX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX6→partner) and Y-score (partner→SIX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.229	+2.999	.010	.035	3	1
UCEC	GAPDH →	+0.570	+2.584	.022	.011	3	1
UCEC	NDRG1_pT346 →	-0.497	-2.584	.029	.011	3	1
UCEC	p21 →	+0.223	+2.820	.012	.035	3	1
UCEC	p70-S6K_pT389 →	-0.178	-2.990	.045	.036	3	1
UCEC	Annexin-1 →	+0.638	+3.189	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

SIX6 survival (RNA) · tumor vs normal (RNA) · all SIX6 data types