Across TCGA cell cohorts, SIX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 664 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SIX6-associated GO terms across cancer lineages are Positive regulation of monoatomic ion transport, Positive regulation of dendrite morphogenesis, and Positive regulation of cell morphogenesis. Each is linked with SIX6 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIX6-to-partner and partner-to-SIX6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX6→partner) and Y-score (partner→SIX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of monoatomic ion transport →	-0.057	-0.004	.003	.001	3	6
OESOPHAGUS	Positive regulation of dendrite morphogenesis →	+0.095	+0.005	<.001	.002	3	5
OESOPHAGUS	Positive regulation of cell morphogenesis →	+0.098	+0.004	<.001	.009	3	5
BREAST	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.058	+0.016	.002	.008	3	4
LUNG_SCLC	Cell adhesion mediated by integrin →	-0.143	-1.018	<.001	.004	3	4
OESOPHAGUS	Myoblast fusion →	-0.136	-0.004	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 664 associations by consensus.

Exploration

SIX6 survival (RNA) · tumor vs normal (RNA) · all SIX6 data types